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TY - JOUR AU - Heemskerk, Jill AU - DiNardo, Stephen AU - Kostriken, Richard AU - O'Farrell, Patrick H. PY - 1991 DA - 1991/08/01 TI - Multiple modes of engrailed regulation in the progression towards cell fate determination JO - Nature SP - 404 EP - 410 VL - 352 IS - 6334 AB - The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed- independent mode of maintenance. SN - 1476-4687 UR - https://doi.org/10.1038/352404a0 DO - 10.1038/352404a0 ID - Heemskerk1991 ER -