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TY - JOUR AU - Harding, Fiona A. AU - McArthur, James G. AU - Gross, Jane A. AU - Raulet, David H. AU - Allison, James P. PY - 1992 DA - 1992/04/01 TI - CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones JO - Nature SP - 607 EP - 609 VL - 356 IS - 6370 AB - OCCUPANCY of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required1. Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state of clonal anergy. This requirement for two stimuli for T-cell activation could have an important role in vivo in establishing peripheral tolerance to antigens not encountered in the thymus1,2. The receptor on T cells required for the co-stimulatory stimulus involved in the prevention of anergy has not been identified. The human T-cell antigen CD28 provides a signal that can synergize with T-cell antigen receptor stimulation in activating T cells to proliferate and secrete lymphokines3–6. Here we report that a monoclonal antibody against the murine homologue of CD28 (ref. 7; J.A.G. et al., manuscript in preparation) can provide a co-stimulatory signal to naive CD4+ T cells and to T-cell clones. Moreover, we demonstrate that this co-stimulatory signal can block the induction of anergy in T-cell clones. SN - 1476-4687 UR - https://doi.org/10.1038/356607a0 DO - 10.1038/356607a0 ID - Harding1992 ER -