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TY - JOUR AU - Strathdee, Craig A. AU - Gavish, Hanna AU - Shannon, William R. AU - Buchwald, Manuel PY - 1992 DA - 1992/04/01 TI - Cloning of cDNAs for Fanconi's anaemia by functional complementation JO - Nature SP - 763 EP - 767 VL - 356 IS - 6372 AB - Fanconi's anaemia is a rare autosomal recessive disorder characterized by progressive pan-cytopaenia and a cellular hypersensitivity to DNA crosslinking agents. Four genetic complementation groups have been identified so far, and here we use a functional complementation method to clone complementary DNAs that correct the defect of group C cells. The cDNAs encode alternatively processed transcripts of a new gene, designated FACC, which is mutated in group C patients. The predicted FACC polypeptide does not contain any motifs common to other proteins and so represents a new gene involved in the cellular response to DNA damage. SN - 1476-4687 UR - https://doi.org/10.1038/356763a0 DO - 10.1038/356763a0 ID - Strathdee1992 ER -