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TY - JOUR AU - Kins, Stefan AU - Betz, Heinrich AU - Kirsch, Joachim PY - 2000 DA - 2000/01/01 TI - Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin JO - Nature Neuroscience SP - 22 EP - 29 VL - 3 IS - 1 AB - The formation of postsynaptic GABAA and glycine receptor clusters requires the receptor-associated peripheral membrane protein gephyrin. Here we describe two splice variants of a novel gephyrin-binding protein, termed collybistin I and II, which belong to the family of dbl-like GDP/GTP exchange factors (GEFs). Co-expression of collybistin II with gephyrin induced the formation of submembrane gephyrin aggregates that accumulate hetero-oligomeric glycine receptors. Our data suggest that collybistin II regulates the membrane deposition of gephyrin by activating a GTPase of the Rho/Rac family. Therefore, this protein may be an important determinant of inhibitory postsynaptic membrane formation and plasticity. SN - 1546-1726 UR - https://doi.org/10.1038/71096 DO - 10.1038/71096 ID - Kins2000 ER -