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TY - JOUR AU - O'Hagan, Rónán C. AU - Schreiber-Agus, Nicole AU - Chen, Ken AU - David, Gregory AU - Engelman, Jeffrey A. AU - Schwab, Richard AU - Alland, Leila AU - Thomson, Cole AU - Ronning, Donald R. AU - Sacchettini, James C. AU - Meltzer, Paul AU - DePinho, Ronald A. PY - 2000 DA - 2000/02/01 TI - Gene-target recognition among members of the Myc superfamily and implications for oncogenesis JO - Nature Genetics SP - 113 EP - 119 VL - 24 IS - 2 AB - Myc and Mad family proteins regulate multiple biological processes through their capacity to influence gene expression directly. Here we show that the basic regions of Myc and Mad proteins are not functionally equivalent in oncogenesis, have separable E-box–binding activities and engage both common and distinct gene targets. Our data support the view that the opposing biological actions of Myc and Mxi1 extend beyond reciprocal regulation of common gene targets. Identification of differentially regulated gene targets provides a framework for understanding the mechanism through which the Myc superfamily governs the growth, proliferation and survival of normal and neoplastic cells. SN - 1546-1718 UR - https://doi.org/10.1038/72761 DO - 10.1038/72761 ID - O'Hagan2000 ER -