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TY - JOUR AU - Rutschmann, Sophie AU - Jung, Alain C. AU - Zhou, Rui AU - Silverman, Neal AU - Hoffmann, Jules A. AU - Ferrandon, Dominique PY - 2000 DA - 2000/10/01 TI - Role of Drosophila IKKγ in a Toll-independent antibacterial immune response JO - Nature Immunology SP - 342 EP - 347 VL - 1 IS - 4 AB - We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the Drosophila homolog of the mammalian I-κB kinase (IKK) complex component IKKγ (also called NEMO). Our data show that Drosophila IKKγ is required for the Relish-dependent immune induction of the genes encoding antibacterial peptides and for resistance to infections by Escherichia coli. However, it is not required for the Toll-DIF–dependent antifungal host defense. The results indicate distinct control mechanisms of the Rel-like transactivators DIF and Relish in the Drosophila innate immune response and show that Drosophila Toll does not signal through a IKKγ-dependent signaling complex. Thus, in contrast to the vertebrate inflammatory response, IKKγ is required for the activation of only one immune signaling pathway in Drosophila. SN - 1529-2916 UR - https://doi.org/10.1038/79801 DO - 10.1038/79801 ID - Rutschmann2000 ER -