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TY - JOUR AU - Ma, Zhigui AU - Morris, Stephan W. AU - Valentine, Virginia AU - L, Martin AU - Herbrick, Jo-Anne AU - Cui, Xiaoli AU - Bouman, Derek AU - Li, Yue AU - Mehta, Perdeep K. AU - Nizetic, Dean AU - Kaneko, Yasuhiko AU - Chan, Godfrey C.F. AU - Chan, Li C. AU - Squire, Jeremy AU - Scherer, Stephen W. AU - Hitzler, Johann K. PY - 2001 DA - 2001/07/01 TI - Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia JO - Nature Genetics SP - 220 EP - 221 VL - 28 IS - 3 AB - t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain. SN - 1546-1718 UR - https://doi.org/10.1038/90054 DO - 10.1038/90054 ID - Ma2001 ER -