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TY - JOUR AU - McCauley, David W. AU - Bronner-Fraser, Marianne PY - 2006 DA - 2006/06/01 TI - Importance of SoxE in neural crest development and the evolution of the pharynx JO - Nature SP - 750 EP - 752 VL - 441 IS - 7094 AB - Neural crest cells are a defining character of vertebrates, patterning the face and much of the head and pharyngeal or gill region in the embryo. In the primitive jawless vertebrates known as lampreys, however, the pharynx is structurally very different from that of jawed vertebrates, raising questions about the role of the neural crest in patterning homologous structures. An experiment using targeted misexpression of SoxE genes, which pattern the head in jawed vertebrates, confirms that they fulfil similar functions in lampreys. So regardless of structural differences, the pharyngeal structures of all vertebrates do appear to be homologous. SN - 1476-4687 UR - https://doi.org/10.1038/nature04691 DO - 10.1038/nature04691 ID - McCauley2006 ER -