(original) (raw)

TY - JOUR AU - Cloos, Paul A. C. AU - Christensen, Jesper AU - Agger, Karl AU - Maiolica, Alessio AU - Rappsilber, Juri AU - Antal, Torben AU - Hansen, Klaus H. AU - Helin, Kristian PY - 2006 DA - 2006/07/01 TI - The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3 JO - Nature SP - 307 EP - 311 VL - 442 IS - 7100 AB - Two papers in this issue identify enzymes capable of demethylating a trimethyl group from the Lys 9 residue of histone H3 — a 'mark' required for the establishment of heterochromatin and previously considered stable. Cloos et al. show that GASC1, a member of the JMJD2 enzyme family, can disrupt heterochromatin structure when overexpressed and may contribute to tumour development. Klose et al. show that overexpression of JHDM3A, also a JMJD2-type enzyme, disrupts heterochromatin structure. It may function in euchromatin to regulate transcription. SN - 1476-4687 UR - https://doi.org/10.1038/nature04837 DO - 10.1038/nature04837 ID - Cloos2006 ER -