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TY - JOUR AU - Zahradka, Ksenija AU - Slade, Dea AU - Bailone, Adriana AU - Sommer, Suzanne AU - Averbeck, Dietrich AU - Petranovic, Mirjana AU - Lindner, Ariel B. AU - Radman, Miroslav PY - 2006 DA - 2006/10/01 TI - Reassembly of shattered chromosomes in Deinococcus radiodurans JO - Nature SP - 569 EP - 573 VL - 443 IS - 7111 AB - Deinococcus radiodurans, isolated in the 1950s from canned meat that had gone off despite being sterilized by high-dose radiation, can recover from radiation exposure even though the DNA damage caused completely fragments the genome. How does it achieve this remarkable feat? It is known to carry multiple copies of its genome and quick and effective DNA repair mechanisms. A new study now shows that first, DNA fragments with regions of complementary sequence find each other and initiate synthesis by a DNA polymerase to form long single-stranded ends on the fragments. Then, complementary single-strand tails pair, to regenerate long double-stranded DNA molecules that are processed into the original circular genome. SN - 1476-4687 UR - https://doi.org/10.1038/nature05160 DO - 10.1038/nature05160 ID - Zahradka2006 ER -