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TY - JOUR AU - Pandey, Udai Bhan AU - Nie, Zhiping AU - Batlevi, Yakup AU - McCray, Brett A. AU - Ritson, Gillian P. AU - Nedelsky, Natalia B. AU - Schwartz, Stephanie L. AU - DiProspero, Nicholas A. AU - Knight, Melanie A. AU - Schuldiner, Oren AU - Padmanabhan, Ranjani AU - Hild, Marc AU - Berry, Deborah L. AU - Garza, Dan AU - Hubbert, Charlotte C. AU - Yao, Tso-Pang AU - Baehrecke, Eric H. AU - Taylor, J. Paul PY - 2007 DA - 2007/06/01 TI - HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS JO - Nature SP - 860 EP - 864 VL - 447 IS - 7146 AB - There are two main pathways that rid a cell of the protein misfits accumulated with time, the ubiquitin-proteasome system and autophagy, the self-destruction of a cell's own components through its lysosomal machinery. Work on a Drosophila model of neurodegenerative disease, in which the ubiquitin proteasome system breaks down, shows that autophagy can compensate for this loss. The two protein-destroying pathways are linked in vivo, with the microtubule-associated-histone deacetlyase HDAC6 acting as the link. Expression of HDAC6 is sufficient to induce autophagy and rescue neurodegeneration in the flies. These findings illuminate the relationship between autophagy and the ubiquitin-proteasome system, with implications for the pathogenesis and possible treatment of neurodegenerative proteopathies. SN - 1476-4687 UR - https://doi.org/10.1038/nature05853 DO - 10.1038/nature05853 ID - Pandey2007 ER -