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TY - JOUR AU - Marques-Bonet, Tomas AU - Kidd, Jeffrey M. AU - Ventura, Mario AU - Graves, Tina A. AU - Cheng, Ze AU - Hillier, LaDeana W. AU - Jiang, Zhaoshi AU - Baker, Carl AU - Malfavon-Borja, Ray AU - Fulton, Lucinda A. AU - Alkan, Can AU - Aksay, Gozde AU - Girirajan, Santhosh AU - Siswara, Priscillia AU - Chen, Lin AU - Cardone, Maria Francesca AU - Navarro, Arcadi AU - Mardis, Elaine R. AU - Wilson, Richard K. AU - Eichler, Evan E. PY - 2009 DA - 2009/02/01 TI - A burst of segmental duplications in the genome of the African great ape ancestor JO - Nature SP - 877 EP - 881 VL - 457 IS - 7231 AB - With four primate genome sequences now available — macaque, orang-utan, chimpanzee and human — it has become possible to construct a comparative segmental duplication map of four primate genomes. This has now been done, and the resulting map used to reconstruct the evolutionary history of all human segmental duplications. The ancestral branch leading to humans and the African great apes shows a fourfold acceleration of segmental duplication accumulation at a time when other mutational processes such as single-base-pair mutation were slowing. This apparent burst of activity may be the result of a change in the effective population size or generation time, or imply a period of genomic destabilization. SN - 1476-4687 UR - https://doi.org/10.1038/nature07744 DO - 10.1038/nature07744 ID - Marques-Bonet2009 ER -