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TY - JOUR AU - Liu, Zhenfeng AU - Gandhi, Chris S. AU - Rees, Douglas C. PY - 2009 DA - 2009/09/01 TI - Structure of a tetrameric MscL in an expanded intermediate state JO - Nature SP - 120 EP - 124 VL - 461 IS - 7260 AB - Mechanosensitive channels protect bacteria from osmotic shock by allowing ions to flow across the membrane in response to changes in membrane tension. MscL is one such channel with large conductance, which exhibits several intermediate states between its closed and open forms. The 3.8-Å crystal structure of the Staphylococcus aureus MscL has now been determined in a nonconductive, partially expanded and tetrameric form. SN - 1476-4687 UR - https://doi.org/10.1038/nature08277 DO - 10.1038/nature08277 ID - Liu2009 ER -