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TY - JOUR AU - Morinière, Jeanne AU - Rousseaux, Sophie AU - Steuerwald, Ulrich AU - Soler-López, Montserrat AU - Curtet, Sandrine AU - Vitte, Anne-Laure AU - Govin, Jérôme AU - Gaucher, Jonathan AU - Sadoul, Karin AU - Hart, Darren J. AU - Krijgsveld, Jeroen AU - Khochbin, Saadi AU - Müller, Christoph W. AU - Petosa, Carlo PY - 2009 DA - 2009/10/01 TI - Cooperative binding of two acetylation marks on a histone tail by a single bromodomain JO - Nature SP - 664 EP - 668 VL - 461 IS - 7264 AB - Brdt1 is a bromodomain-containing chromatin protein that can compact hyperacetylated chromatin and has important functions during spermiogenesis. Here, the crystal structure of a bromodomain of Brdt1 bound to an acetylated histone H4 tail reveals a combinatorial mode of binding to post-translational modifications where a single effector module engages two marks on a histone tail. SN - 1476-4687 UR - https://doi.org/10.1038/nature08397 DO - 10.1038/nature08397 ID - Morinière2009 ER -