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TY - JOUR AU - Vastenhouw, Nadine L. AU - Zhang, Yong AU - Woods, Ian G. AU - Imam, Farhad AU - Regev, Aviv AU - Liu, X. Shirley AU - Rinn, John AU - Schier, Alexander F. PY - 2010 DA - 2010/04/01 TI - Chromatin signature of embryonic pluripotency is established during genome activation JO - Nature SP - 922 EP - 926 VL - 464 IS - 7290 AB - To study the changes in chromatin structure that accompany zygotic genome activation and pluripotency during the maternal–zygotic transition (MZT), the genomic locations of histone H3 modifications and RNA polymerase II have been mapped during this transition in zebrafish embryos. H3 lysine 27 trimethylation and H3 lysine 4 trimethylation are only detected after MZT, and evidence is provided that the bivalent chromatin domains in cultured ES cells also exist in embryos. SN - 1476-4687 UR - https://doi.org/10.1038/nature08866 DO - 10.1038/nature08866 ID - Vastenhouw2010 ER -