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TY - JOUR AU - D’Angiolella, Vincenzo AU - Donato, Valerio AU - Vijayakumar, Sangeetha AU - Saraf, Anita AU - Florens, Laurence AU - Washburn, Michael P. AU - Dynlacht, Brian AU - Pagano, Michele PY - 2010 DA - 2010/07/01 TI - SCFCyclin F controls centrosome homeostasis and mitotic fidelity through CP110 degradation JO - Nature SP - 138 EP - 142 VL - 466 IS - 7302 AB - Cyclin F is the founding member of the F-box protein family but its functions are unknown. In contrast to most cyclins, it does not bind or activate cyclin-dependent kinases (CDKs). Here, a protein essential for centrosome duplication, CP110, is identified as a substrate of Cyclin F. CP110 and Cyclin F associate on centrioles during the cell cycle, and Cyclin F is proposed to limit centrosome duplication by targeting CP110 for degradation. SN - 1476-4687 UR - https://doi.org/10.1038/nature09140 DO - 10.1038/nature09140 ID - D’Angiolella2010 ER -