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TY - JOUR AU - Ricci-Vitiani, Lucia AU - Pallini, Roberto AU - Biffoni, Mauro AU - Todaro, Matilde AU - Invernici, Gloria AU - Cenci, Tonia AU - Maira, Giulio AU - Parati, Eugenio Agostino AU - Stassi, Giorgio AU - Larocca, Luigi Maria AU - De Maria, Ruggero PY - 2010 DA - 2010/12/01 TI - Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells JO - Nature SP - 824 EP - 828 VL - 468 IS - 7325 AB - Glioblastomas are aggressive brain cancers that are nourished by an extensive network of blood vessels. Two groups now show that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells and seem to be derived from glioblastoma stem-like cells. This work suggests that some putative cancer stem cells promote cancer growth both directly and indirectly, and may explain the failure of certain anti-angiogenic cancer drugs and aid the design of new therapies. SN - 1476-4687 UR - https://doi.org/10.1038/nature09557 DO - 10.1038/nature09557 ID - Ricci-Vitiani2010 ER -