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TY - JOUR AU - Ferrón, Sacri R. AU - Charalambous, Marika AU - Radford, Elizabeth AU - McEwen, Kirsten AU - Wildner, Hendrik AU - Hind, Eleanor AU - Morante-Redolat, Jose Manuel AU - Laborda, Jorge AU - Guillemot, Francois AU - Bauer, Steven R. AU - Fariñas, Isabel AU - Ferguson-Smith, Anne C. PY - 2011 DA - 2011/07/01 TI - Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis JO - Nature SP - 381 EP - 385 VL - 475 IS - 7356 AB - Life-long neurogenesis is known to occur in some areas of the mammalian adult brain, including in the subventricular zone (SVZ), where interaction between neural precursor cells and resident astrocytes can produced migratory neuroblasts. Here, Anne Ferguson-Smith and colleagues reveal a differential role for the same developmental gene, Dlk1, in neural precursor cells and astrocytes. The gene product, the Notch ligand DLK1, has two isoforms. One is an inductive niche factor secreted by astrocytes, and the other is a membrane-bound isoform required by the neural stem cells themselves to respond to secreted DLK1. Selective changes of imprinting with age modulate the role of Dlk1 in each cell type in mice, regulating neurogenesis when establishing the adult neurogenic niche. The modulation of genomic imprinting in a stem-cell environment adds a previously unrecognized element to epigenetic regulation. SN - 1476-4687 UR - https://doi.org/10.1038/nature10229 DO - 10.1038/nature10229 ID - Ferrón2011 ER -