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TY - JOUR AU - Morin, Ryan D. AU - Mendez-Lago, Maria AU - Mungall, Andrew J. AU - Goya, Rodrigo AU - Mungall, Karen L. AU - Corbett, Richard D. AU - Johnson, Nathalie A. AU - Severson, Tesa M. AU - Chiu, Readman AU - Field, Matthew AU - Jackman, Shaun AU - Krzywinski, Martin AU - Scott, David W. AU - Trinh, Diane L. AU - Tamura-Wells, Jessica AU - Li, Sa AU - Firme, Marlo R. AU - Rogic, Sanja AU - Griffith, Malachi AU - Chan, Susanna AU - Yakovenko, Oleksandr AU - Meyer, Irmtraud M. AU - Zhao, Eric Y. AU - Smailus, Duane AU - Moksa, Michelle AU - Chittaranjan, Suganthi AU - Rimsza, Lisa AU - Brooks-Wilson, Angela AU - Spinelli, John J. AU - Ben-Neriah, Susana AU - Meissner, Barbara AU - Woolcock, Bruce AU - Boyle, Merrill AU - McDonald, Helen AU - Tam, Angela AU - Zhao, Yongjun AU - Delaney, Allen AU - Zeng, Thomas AU - Tse, Kane AU - Butterfield, Yaron AU - Birol, Inanç AU - Holt, Rob AU - Schein, Jacqueline AU - Horsman, Douglas E. AU - Moore, Richard AU - Jones, Steven J. M. AU - Connors, Joseph M. AU - Hirst, Martin AU - Gascoyne, Randy D. AU - Marra, Marco A. PY - 2011 DA - 2011/08/01 TI - Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma JO - Nature SP - 298 EP - 303 VL - 476 IS - 7360 AB - Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NHL. We analysed RNA-seq data from these and another 113 NHLs to identify genes with candidate mutations, and then re-sequenced tumour and matched normal DNA from these cases to confirm 109 genes with multiple somatic mutations. Genes with roles in histone modification were frequent targets of somatic mutation. For example, 32% of DLBCL and 89% of FL cases had somatic mutations in MLL2, which encodes a histone methyltransferase, and 11.4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B, a calcium-regulated gene that cooperates with CREBBP and EP300 in acetylating histones. Our analysis suggests a previously unappreciated disruption of chromatin biology in lymphomagenesis. SN - 1476-4687 UR - https://doi.org/10.1038/nature10351 DO - 10.1038/nature10351 ID - Morin2011 ER -