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TY - JOUR AU - Keane, Thomas M. AU - Goodstadt, Leo AU - Danecek, Petr AU - White, Michael A. AU - Wong, Kim AU - Yalcin, Binnaz AU - Heger, Andreas AU - Agam, Avigail AU - Slater, Guy AU - Goodson, Martin AU - Furlotte, Nicholas A. AU - Eskin, Eleazar AU - Nellåker, Christoffer AU - Whitley, Helen AU - Cleak, James AU - Janowitz, Deborah AU - Hernandez-Pliego, Polinka AU - Edwards, Andrew AU - Belgard, T. Grant AU - Oliver, Peter L. AU - McIntyre, Rebecca E. AU - Bhomra, Amarjit AU - Nicod, Jérôme AU - Gan, Xiangchao AU - Yuan, Wei AU - van der Weyden, Louise AU - Steward, Charles A. AU - Bala, Sendu AU - Stalker, Jim AU - Mott, Richard AU - Durbin, Richard AU - Jackson, Ian J. AU - Czechanski, Anne AU - Guerra-Assunção, José Afonso AU - Donahue, Leah Rae AU - Reinholdt, Laura G. AU - Payseur, Bret A. AU - Ponting, Chris P. AU - Birney, Ewan AU - Flint, Jonathan AU - Adams, David J. PY - 2011 DA - 2011/09/01 TI - Mouse genomic variation and its effect on phenotypes and gene regulation JO - Nature SP - 289 EP - 294 VL - 477 IS - 7364 AB - We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, revealing that at least 12% of transcripts show a significant tissue-specific expression bias. By identifying candidate functional variants at 718 quantitative trait loci we show that the molecular nature of functional variants and their position relative to genes vary according to the effect size of the locus. These sequences provide a starting point for a new era in the functional analysis of a key model organism. SN - 1476-4687 UR - https://doi.org/10.1038/nature10413 DO - 10.1038/nature10413 ID - Keane2011 ER -