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TY - JOUR AU - Mazur, Pawel K. AU - Reynoird, Nicolas AU - Khatri, Purvesh AU - Jansen, Pascal W. T. C. AU - Wilkinson, Alex W. AU - Liu, Shichong AU - Barbash, Olena AU - Van Aller, Glenn S. AU - Huddleston, Michael AU - Dhanak, Dashyant AU - Tummino, Peter J. AU - Kruger, Ryan G. AU - Garcia, Benjamin A. AU - Butte, Atul J. AU - Vermeulen, Michiel AU - Sage, Julien AU - Gozani, Or PY - 2014 DA - 2014/06/01 TI - SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer JO - Nature SP - 283 EP - 287 VL - 510 IS - 7504 AB - SMYD3 is a methyltransferase overexpressed in several human tumours; here methylation of the MAP3K2 kinase by SMYD3 is shown to be critical for Ras-induced tumour development in mouse models and human tumour cells, showing an unexpected role for methylation in a kinase signalling pathway and revealing a candidate therapeutic target. SN - 1476-4687 UR - https://doi.org/10.1038/nature13320 DO - 10.1038/nature13320 ID - Mazur2014 ER -