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TY - JOUR AU - Gregorieff, Alex AU - Liu, Yu AU - Inanlou, Mohammad R. AU - Khomchuk, Yuliya AU - Wrana, Jeffrey L. PY - 2015 DA - 2015/10/01 TI - Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer JO - Nature SP - 715 EP - 718 VL - 526 IS - 7575 AB - This study finds that the Hippo pathway is essential for gut epithelial regeneration and tumour initiation; the Hippo component Yap holds off differentiation of intestinal stem cells to Paneth cells to promote a survival and self-renewal regenerative program through activation of the Egfr pathway. SN - 1476-4687 UR - https://doi.org/10.1038/nature15382 DO - 10.1038/nature15382 ID - Gregorieff2015 ER -