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TY - JOUR AU - Gordon, Sydney R. AU - Maute, Roy L. AU - Dulken, Ben W. AU - Hutter, Gregor AU - George, Benson M. AU - McCracken, Melissa N. AU - Gupta, Rohit AU - Tsai, Jonathan M. AU - Sinha, Rahul AU - Corey, Daniel AU - Ring, Aaron M. AU - Connolly, Andrew J. AU - Weissman, Irving L. PY - 2017 DA - 2017/05/01 TI - PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity JO - Nature SP - 495 EP - 499 VL - 545 IS - 7655 AB - Mouse and human tumour-associated macrophages express PD-1, which increases with cancer stage and induces decreased phagocytosis by macrophages; by contrast, PD-L1 removal increases phagocytosis in vivo, decreases tumour burden and increases survival of mice. SN - 1476-4687 UR - https://doi.org/10.1038/nature22396 DO - 10.1038/nature22396 ID - Gordon2017 ER -