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TY - JOUR AU - Markoulaki, Styliani AU - Hanna, Jacob AU - Beard, Caroline AU - Carey, Bryce W AU - Cheng, Albert W AU - Lengner, Christopher J AU - Dausman, Jessica A AU - Fu, Dongdong AU - Gao, Qing AU - Wu, Su AU - Cassady, John P AU - Jaenisch, Rudolf PY - 2009 DA - 2009/02/01 TI - Transgenic mice with defined combinations of drug-inducible reprogramming factors JO - Nature Biotechnology SP - 169 EP - 171 VL - 27 IS - 2 AB - The generation of induced pluripotent stem cells might be improved by replacing the reprogramming transgenes with small molecules. To provide cells suitable for small-molecule screening, Markoulaki et al. segregate the transgenes Oct4, Sox2, Klf4 and c-Myc through breeding, creating mice carrying all possible combinations of the four factors. SN - 1546-1696 UR - https://doi.org/10.1038/nbt.1520 DO - 10.1038/nbt.1520 ID - Markoulaki2009 ER -