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TY - JOUR AU - Haidet-Phillips, Amanda M AU - Hester, Mark E AU - Miranda, Carlos J AU - Meyer, Kathrin AU - Braun, Lyndsey AU - Frakes, Ashley AU - Song, SungWon AU - Likhite, Shibi AU - Murtha, Matthew J AU - Foust, Kevin D AU - Rao, Meghan AU - Eagle, Amy AU - Kammesheidt, Anja AU - Christensen, Ashley AU - Mendell, Jerry R AU - Burghes, Arthur H M AU - Kaspar, Brian K PY - 2011 DA - 2011/09/01 TI - Astrocytes from familial and sporadic ALS patients are toxic to motor neurons JO - Nature Biotechnology SP - 824 EP - 828 VL - 29 IS - 9 AB - The similarities and differences between the disease mechanisms underlying the sporadic and familial forms of amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) are poorly characterized. Using human astrocytes derived from neural progenitor cells obtained from cadaveric spinal cords, Haidet-Phillips et al. propose that sporadic and familial ALS share common pathogenic pathways involving astrocyte-mediated damage. SN - 1546-1696 UR - https://doi.org/10.1038/nbt.1957 DO - 10.1038/nbt.1957 ID - Haidet-Phillips2011 ER -