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TY - JOUR AU - Sorrentino, Alessandro AU - Thakur, Noopur AU - Grimsby, Susanne AU - Marcusson, Anders AU - von Bulow, Verena AU - Schuster, Norbert AU - Zhang, Shouting AU - Heldin, Carl-Henrik AU - Landström, Maréne PY - 2008 DA - 2008/10/01 TI - The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner JO - Nature Cell Biology SP - 1199 EP - 1207 VL - 10 IS - 10 AB - In response to TGFβ, and in contrast to canonical SMAD activation, TGFβ receptor kinase activity is dispensable for activating the TAK1 kinase, whereas the TRAF6 ubiquitin ligase is neccessary. SN - 1476-4679 UR - https://doi.org/10.1038/ncb1780 DO - 10.1038/ncb1780 ID - Sorrentino2008 ER -