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TY - JOUR AU - VARMUS, HAROLD E. AU - LEVINSON, WARREN E. AU - BISHOP, J. MICHAEL PY - 1971 DA - 1971/09/01 TI - Extent of Transcription by the RNA-dependent DNA Polymerase of Rous Sarcoma Virus JO - Nature New Biology SP - 19 EP - 21 VL - 233 IS - 35 AB - THE identification of RNA-dependent DNA polymerases as components of RNA tumour viruses1–6 is consistent with Temin's provirus theory, which contends that RNA tumour viruses transform cells by integrating DNA copies of their genome into host cell chromosomes7,8. Transcription of the entire RNA genome into double stranded DNA would permit an integrated provirus to serve as template for the replication of new viral RNA, but the DNA molecules produced by these polymerases are small compared with their viral RNA templates: formation of hybrids of short DNA pieces transcribed against 70S RNA3,6,9 is followed by incorporation of most of this single stranded DNA into similarly small double stranded DNA of 4-10S10–12. SN - 2058-1092 UR - https://doi.org/10.1038/newbio233019a0 DO - 10.1038/newbio233019a0 ID - VARMUS1971 ER -