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TY - JOUR AU - Simons, Yuval B AU - Turchin, Michael C AU - Pritchard, Jonathan K AU - Sella, Guy PY - 2014 DA - 2014/03/01 TI - The deleterious mutation load is insensitive to recent population history JO - Nature Genetics SP - 220 EP - 224 VL - 46 IS - 3 AB - Jonathan Pritchard, Guy Sella and colleagues report an analysis using population genetic models to show that recent human demography is likely to have had little impact on the average burden of deleterious mutations. They examine two large exome sequence datasets and find that individuals of west African and European ancestry carry similar burdens of damaging mutations. SN - 1546-1718 UR - https://doi.org/10.1038/ng.2896 DO - 10.1038/ng.2896 ID - Simons2014 ER -