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TY - JOUR AU - Matmati, Mourad AU - Jacques, Peggy AU - Maelfait, Jonathan AU - Verheugen, Eveline AU - Kool, Mirjam AU - Sze, Mozes AU - Geboes, Lies AU - Louagie, Els AU - Guire, Conor Mc AU - Vereecke, Lars AU - Chu, Yuanyuan AU - Boon, Louis AU - Staelens, Steven AU - Matthys, Patrick AU - Lambrecht, Bart N AU - Schmidt-Supprian, Marc AU - Pasparakis, Manolis AU - Elewaut, Dirk AU - Beyaert, Rudi AU - van Loo, Geert PY - 2011 DA - 2011/09/01 TI - A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis JO - Nature Genetics SP - 908 EP - 912 VL - 43 IS - 9 AB - Geert van Loo, Rudi Beyaert, Dirk Elewaut and colleagues report that myeloid-specific deletion of Tnfaip3 in mice causes spontaneous destructive polyarthritis that resembles rheumatoid arthritis. Tnfaip3 encodes the A20 protein, which is involved in negative regulation of NF-κB signaling in response to proinflammatory stimuli. SN - 1546-1718 UR - https://doi.org/10.1038/ng.874 DO - 10.1038/ng.874 ID - Matmati2011 ER -