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TY - JOUR AU - Parker, J Alex AU - Arango, Margarita AU - Abderrahmane, Salima AU - Lambert, Emmanuel AU - Tourette, Cendrine AU - Catoire, Hélène AU - Néri, Christian PY - 2005 DA - 2005/04/01 TI - Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons JO - Nature Genetics SP - 349 EP - 350 VL - 37 IS - 4 AB - We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine–specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines. SN - 1546-1718 UR - https://doi.org/10.1038/ng1534 DO - 10.1038/ng1534 ID - Parker2005 ER -