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TY - JOUR AU - Smyth, Deborah J AU - Cooper, Jason D AU - Bailey, Rebecca AU - Field, Sarah AU - Burren, Oliver AU - Smink, Luc J AU - Guja, Cristian AU - Ionescu-Tirgoviste, Constantin AU - Widmer, Barry AU - Dunger, David B AU - Savage, David A AU - Walker, Neil M AU - Clayton, David G AU - Todd, John A PY - 2006 DA - 2006/06/01 TI - A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region JO - Nature Genetics SP - 617 EP - 619 VL - 38 IS - 6 AB - In this study we report convincing statistical support for a sixth type 1 diabetes (T1D) locus in the innate immunity viral RNA receptor gene region IFIH1 (also known as mda-5 or Helicard) on chromosome 2q24.3. We found the association in an interim analysis of a genome-wide nonsynonymous SNP (nsSNP) scan, and we validated it in a case-control collection and replicated it in an independent family collection. In 4,253 cases, 5,842 controls and 2,134 parent-child trio genotypes, the risk ratio for the minor allele of the nsSNP rs1990760 A → G (A946T) was 0.86 (95% confidence interval = 0.82–0.90) at P = 1.42 × 10−10. SN - 1546-1718 UR - https://doi.org/10.1038/ng1800 DO - 10.1038/ng1800 ID - Smyth2006 ER -