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TY - JOUR AU - Sebaihia, Mohammed AU - Wren, Brendan W AU - Mullany, Peter AU - Fairweather, Neil F AU - Minton, Nigel AU - Stabler, Richard AU - Thomson, Nicholas R AU - Roberts, Adam P AU - Cerdeño-Tárraga, Ana M AU - Wang, Hongmei AU - Holden, Matthew TG AU - Wright, Anne AU - Churcher, Carol AU - Quail, Michael A AU - Baker, Stephen AU - Bason, Nathalie AU - Brooks, Karen AU - Chillingworth, Tracey AU - Cronin, Ann AU - Davis, Paul AU - Dowd, Linda AU - Fraser, Audrey AU - Feltwell, Theresa AU - Hance, Zahra AU - Holroyd, Simon AU - Jagels, Kay AU - Moule, Sharon AU - Mungall, Karen AU - Price, Claire AU - Rabbinowitsch, Ester AU - Sharp, Sarah AU - Simmonds, Mark AU - Stevens, Kim AU - Unwin, Louise AU - Whithead, Sally AU - Dupuy, Bruno AU - Dougan, Gordon AU - Barrell, Bart AU - Parkhill, Julian PY - 2006 DA - 2006/07/01 TI - The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome JO - Nature Genetics SP - 779 EP - 786 VL - 38 IS - 7 AB - We determined the complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain. Our analysis indicates that a large proportion (11%) of the genome consists of mobile genetic elements, mainly in the form of conjugative transposons. These mobile elements are putatively responsible for the acquisition by C. difficile of an extensive array of genes involved in antimicrobial resistance, virulence, host interaction and the production of surface structures. The metabolic capabilities encoded in the genome show multiple adaptations for survival and growth within the gut environment. The extreme genome variability was confirmed by whole-genome microarray analysis; it may reflect the organism's niche in the gut and should provide information on the evolution of virulence in this organism. SN - 1546-1718 UR - https://doi.org/10.1038/ng1830 DO - 10.1038/ng1830 ID - Sebaihia2006 ER -