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TY - JOUR AU - Gudmundsson, Julius AU - Sulem, Patrick AU - Manolescu, Andrei AU - Amundadottir, Laufey T AU - Gudbjartsson, Daniel AU - Helgason, Agnar AU - Rafnar, Thorunn AU - Bergthorsson, Jon T AU - Agnarsson, Bjarni A AU - Baker, Adam AU - Sigurdsson, Asgeir AU - Benediktsdottir, Kristrun R AU - Jakobsdottir, Margret AU - Xu, Jianfeng AU - Blondal, Thorarinn AU - Kostic, Jelena AU - Sun, Jielin AU - Ghosh, Shyamali AU - Stacey, Simon N AU - Mouy, Magali AU - Saemundsdottir, Jona AU - Backman, Valgerdur M AU - Kristjansson, Kristleifur AU - Tres, Alejandro AU - Partin, Alan W AU - Albers-Akkers, Marjo T AU - Godino-Ivan Marcos, Javier AU - Walsh, Patrick C AU - Swinkels, Dorine W AU - Navarrete, Sebastian AU - Isaacs, Sarah D AU - Aben, Katja K AU - Graif, Theresa AU - Cashy, John AU - Ruiz-Echarri, Manuel AU - Wiley, Kathleen E AU - Suarez, Brian K AU - Witjes, J Alfred AU - Frigge, Mike AU - Ober, Carole AU - Jonsson, Eirikur AU - Einarsson, Gudmundur V AU - Mayordomo, Jose I AU - Kiemeney, Lambertus A AU - Isaacs, William B AU - Catalona, William J AU - Barkardottir, Rosa B AU - Gulcher, Jeffrey R AU - Thorsteinsdottir, Unnur AU - Kong, Augustine AU - Stefansson, Kari PY - 2007 DA - 2007/05/01 TI - Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 JO - Nature Genetics SP - 631 EP - 637 VL - 39 IS - 5 AB - Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions1, with African American men having among the highest worldwide incidence and mortality rates2. Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered3, accounts for about 11%–13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans. We made the current discovery through a genome-wide association scan of 1,453 affected Icelandic individuals and 3,064 controls using the Illumina HumanHap300 BeadChip followed by four replication studies. A key step in the discovery was the construction of a 14-SNP haplotype that efficiently tags a relatively uncommon (2%–4%) susceptibility variant in individuals of European descent that happens to be very common (∼42%) in African Americans. The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis. SN - 1546-1718 UR - https://doi.org/10.1038/ng1999 DO - 10.1038/ng1999 ID - Gudmundsson2007 ER -