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TY - JOUR AU - Keinan, Alon AU - Mullikin, James C AU - Patterson, Nick AU - Reich, David PY - 2007 DA - 2007/10/01 TI - Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans JO - Nature Genetics SP - 1251 EP - 1255 VL - 39 IS - 10 AB - Large data sets on human genetic variation have been collected recently, but their usefulness for learning about history and natural selection has been limited by biases in the ways polymorphisms were chosen. We report large subsets of SNPs from the International HapMap Project1,2 that allow us to overcome these biases and to provide accurate measurement of a quantity of crucial importance for understanding genetic variation: the allele frequency spectrum. Our analysis shows that East Asian and northern European ancestors shared the same population bottleneck expanding out of Africa but that both also experienced more recent genetic drift, which was greater in East Asians. SN - 1546-1718 UR - https://doi.org/10.1038/ng2116 DO - 10.1038/ng2116 ID - Keinan2007 ER -