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TY - JOUR AU - Fernandes-Alnemri, Teresa AU - Yu, Je-Wook AU - Juliana, Christine AU - Solorzano, Leobaldo AU - Kang, Seokwon AU - Wu, Jianghong AU - Datta, Pinaki AU - McCormick, Margaret AU - Huang, Lan AU - McDermott, Erin AU - Eisenlohr, Laurence AU - Landel, Carlisle P AU - Alnemri, Emad S PY - 2010 DA - 2010/05/01 TI - The AIM2 inflammasome is critical for innate immunity to Francisella tularensis JO - Nature Immunology SP - 385 EP - 393 VL - 11 IS - 5 AB - The AIM2 inflammasome induces maturation of the proinflammatory cytokines IL-1β and IL-18. Using AIM2-deficient mice, Fitzgerald and colleagues and Alnemri and colleagues show that the AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. SN - 1529-2916 UR - https://doi.org/10.1038/ni.1859 DO - 10.1038/ni.1859 ID - Fernandes-Alnemri2010 ER -