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TY - JOUR AU - Steinke, Farrah C AU - Yu, Shuyang AU - Zhou, Xinyuan AU - He, Bing AU - Yang, Wenjing AU - Zhou, Bo AU - Kawamoto, Hiroshi AU - Zhu, Jun AU - Tan, Kai AU - Xue, Hai-Hui PY - 2014 DA - 2014/07/01 TI - TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence Cd4 in CD8+ T cells JO - Nature Immunology SP - 646 EP - 656 VL - 15 IS - 7 AB - TCF-1 and LEF-1 are essential for early T cell development. Xue and colleagues show that in DP thymocytes, they control CD4+-versus-CD8+ T cell lineage 'decisions' and contribute to the establishment of CD8+ T cell identity. SN - 1529-2916 UR - https://doi.org/10.1038/ni.2897 DO - 10.1038/ni.2897 ID - Steinke2014 ER -