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TY - JOUR AU - Uematsu, Satoshi AU - Jang, Myoung Ho AU - Chevrier, Nicolas AU - Guo, Zijin AU - Kumagai, Yutaro AU - Yamamoto, Masahiro AU - Kato, Hiroki AU - Sougawa, Nagako AU - Matsui, Hidenori AU - Kuwata, Hirotaka AU - Hemmi, Hiroaki AU - Coban, Cevayir AU - Kawai, Taro AU - Ishii, Ken J AU - Takeuchi, Osamu AU - Miyasaka, Masayuki AU - Takeda, Kiyoshi AU - Akira, Shizuo PY - 2006 DA - 2006/08/01 TI - Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells JO - Nature Immunology SP - 868 EP - 874 VL - 7 IS - 8 AB - Toll-like receptors (TLRs) recognize distinct microbial components and induce innate immune responses. TLR5 is triggered by bacterial flagellin. Here we generated Tlr5−/− 1mice and assessed TLR5 function in vivo. Unlike other TLRs, TLR5 was not expressed on conventional dendritic cells or macrophages. In contrast, TLR5 was expressed mainly on intestinal CD11c+ lamina propria cells (LPCs). CD11c+ LPCs detected pathogenic bacteria and secreted proinflammatory cytokines in a TLR5-dependent way. However, CD11c+ LPCs do not express TLR4 and did not secrete proinflammatory cytokines after exposure to a commensal bacterium. Notably, transport of pathogenic Salmonella typhimurium from the intestinal tract to mesenteric lymph nodes was impaired in Tlr5−/− mice. These data suggest that CD11c+ LPCs, via TLR5, detect and are used by pathogenic bacteria in the intestinal lumen. SN - 1529-2916 UR - https://doi.org/10.1038/ni1362 DO - 10.1038/ni1362 ID - Uematsu2006 ER -