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TY - JOUR AU - Seder, Robert A AU - Ahmed, Rafi PY - 2003 DA - 2003/09/01 TI - Similarities and differences in CD4+ and CD8+ effector and memory T cell generation JO - Nature Immunology SP - 835 EP - 842 VL - 4 IS - 9 AB - Naive CD4+ and CD8+ T cells undergo unique developmental programs after activation, resulting in the generation of effector and long-lived memory T cells. Recent evidence indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell differentiation. This review compares and contrasts how naive CD4+ and CD8+ T cells make the transition to effector and/or memory cells and discusses the implications of these findings for vaccine development. SN - 1529-2916 UR - https://doi.org/10.1038/ni969 DO - 10.1038/ni969 ID - Seder2003 ER -