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TY - JOUR AU - Cho, Hyelim AU - Proll, Sean C AU - Szretter, Kristy J AU - Katze, Michael G AU - Gale, Michael AU - Diamond, Michael S PY - 2013 DA - 2013/04/01 TI - Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses JO - Nature Medicine SP - 458 EP - 464 VL - 19 IS - 4 AB - Different types of neurons are differentially susceptible to West Nile virus (WNV) infection. Michael Diamond and colleagues now show that cerebellar granule cell neurons (GCN) have a higher basal level of expression of type I interferon–inducible genes than cortical neurons, making GCN more resistant to infection by a variety of positive-stranded RNA viruses, including WNV. SN - 1546-170X UR - https://doi.org/10.1038/nm.3108 DO - 10.1038/nm.3108 ID - Cho2013 ER -