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TY - JOUR AU - Jang, Cholsoon AU - Oh, Sungwhan F AU - Wada, Shogo AU - Rowe, Glenn C AU - Liu, Laura AU - Chan, Mun Chun AU - Rhee, James AU - Hoshino, Atsushi AU - Kim, Boa AU - Ibrahim, Ayon AU - Baca, Luisa G AU - Kim, Esl AU - Ghosh, Chandra C AU - Parikh, Samir M AU - Jiang, Aihua AU - Chu, Qingwei AU - Forman, Daniel E AU - Lecker, Stewart H AU - Krishnaiah, Saikumari AU - Rabinowitz, Joshua D AU - Weljie, Aalim M AU - Baur, Joseph A AU - Kasper, Dennis L AU - Arany, Zoltan PY - 2016 DA - 2016/04/01 TI - A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance JO - Nature Medicine SP - 421 EP - 426 VL - 22 IS - 4 AB - Fatty acid transport from blood vessels to skeletal muscle, across endothelial cells, is regulated by the branched chain amino acid metabolite 3-hydroxy-isobutyrate. This finding provides a mechanistic explanation for the link between high levels of branched chain amino acids and diabetes. SN - 1546-170X UR - https://doi.org/10.1038/nm.4057 DO - 10.1038/nm.4057 ID - Jang2016 ER -