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TY - JOUR AU - Vu, Ly P AU - Pickering, Brian F AU - Cheng, Yuanming AU - Zaccara, Sara AU - Nguyen, Diu AU - Minuesa, Gerard AU - Chou, Timothy AU - Chow, Arthur AU - Saletore, Yogesh AU - MacKay, Matthew AU - Schulman, Jessica AU - Famulare, Christopher AU - Patel, Minal AU - Klimek, Virginia M AU - Garrett-Bakelman, Francine E AU - Melnick, Ari AU - Carroll, Martin AU - Mason, Christopher E AU - Jaffrey, Samie R AU - Kharas, Michael G PY - 2017 DA - 2017/11/01 TI - The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells JO - Nature Medicine SP - 1369 EP - 1376 VL - 23 IS - 11 AB - The N6-methyladenosine (m6A) modification in mRNAs, generated by the enzyme METTL3, controls normal human hematopoietic stem/progenitor cell differentiation and maintains the undifferentiated leukemic phenotype of human acute myeloid leukemia cells. SN - 1546-170X UR - https://doi.org/10.1038/nm.4416 DO - 10.1038/nm.4416 ID - Vu2017 ER -