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TY - JOUR AU - Pálmer, Héctor G AU - Larriba, María Jesús AU - García, José Miguel AU - Ordóñez-Morán, Paloma AU - Peña, Cristina AU - Peiró, Sandra AU - Puig, Isabel AU - Rodríguez, Rufo AU - de la Fuente, Ricardo AU - Bernad, Antonio AU - Pollán, Marina AU - Bonilla, Félix AU - Gamallo, Carlos AU - de Herreros, Antonio García AU - Muñoz, Alberto PY - 2004 DA - 2004/09/01 TI - The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer JO - Nature Medicine SP - 917 EP - 919 VL - 10 IS - 9 AB - Several non-hypercalcemic analogs of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognosis but is lost during tumor progression. We show that the SNAIL transcription factor represses VDR gene expression in human colon cancer cells and blocks the antitumor action of EB1089, a 1,25(OH)2D3 analog, in xenografted mice. In human colon cancers, elevated SNAIL expression correlates with downregulation of VDR. SN - 1546-170X UR - https://doi.org/10.1038/nm1095 DO - 10.1038/nm1095 ID - Pálmer2004 ER -