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TY - JOUR AU - Kitada, Kazuhiro AU - Ishishita, Satoshi AU - Tosaka, Keiko AU - Takahashi, Ri-ichi AU - Ueda, Masatsugu AU - Keng, Vincent W AU - Horie, Kyoji AU - Takeda, Junji PY - 2007 DA - 2007/02/01 TI - Transposon-tagged mutagenesis in the rat JO - Nature Methods SP - 131 EP - 133 VL - 4 IS - 2 AB - Although the laboratory rat (Rattus norvegicus) is an indispensable experimental animal for biomedical research and drug development, the lack of embryonic stem cell lines hampers gene-knockout studies. Here we report the successful generation of insertional mutant rats using the Sleeping Beauty (SB) transposon system. This would benefit a variety of biomedical research fields for which the rat model is better suited than the mouse model. SN - 1548-7105 UR - https://doi.org/10.1038/nmeth1002 DO - 10.1038/nmeth1002 ID - Kitada2007 ER -