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TY - JOUR AU - Gothelf, Doron AU - Eliez, Stephan AU - Thompson, Tracy AU - Hinard, Christine AU - Penniman, Lauren AU - Feinstein, Carl AU - Kwon, Hower AU - Jin, Shuting AU - Jo, Booil AU - Antonarakis, Stylianos E AU - Morris, Michael A AU - Reiss, Allan L PY - 2005 DA - 2005/11/01 TI - COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome JO - Nature Neuroscience SP - 1500 EP - 1502 VL - 8 IS - 11 AB - Although schizophrenia is strongly hereditary, there are limited data regarding biological risk factors and pathophysiological processes. In this longitudinal study of adolescents with 22q11.2 deletion syndrome, we identified the catechol-O-methyltransferase low-activity allele (COMTL) as a risk factor for decline in prefrontal cortical volume and cognition, as well as for the consequent development of psychotic symptoms during adolescence. The 22q11.2 deletion syndrome is a promising model for identifying biomarkers related to the development of schizophrenia. SN - 1546-1726 UR - https://doi.org/10.1038/nn1572 DO - 10.1038/nn1572 ID - Gothelf2005 ER -