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TY - JOUR AU - Northoff, Georg AU - Walter, Martin AU - Schulte, Rolf F AU - Beck, Johannes AU - Dydak, Ulrike AU - Henning, Anke AU - Boeker, Heinz AU - Grimm, Simone AU - Boesiger, Peter PY - 2007 DA - 2007/12/01 TI - GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI JO - Nature Neuroscience SP - 1515 EP - 1517 VL - 10 IS - 12 AB - The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level–dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA. SN - 1546-1726 UR - https://doi.org/10.1038/nn2001 DO - 10.1038/nn2001 ID - Northoff2007 ER -