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TY - JOUR AU - Huang, Da Wei AU - Sherman, Brad T AU - Lempicki, Richard A PY - 2009 DA - 2009/01/01 TI - Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources JO - Nature Protocols SP - 44 EP - 57 VL - 4 IS - 1 AB - DAVID bioinformatics resources consists of an integrated biological knowledgebase and analytic tools aimed at systematically extracting biological meaning from large gene/protein lists. This protocol explains how to use DAVID, a high-throughput and integrated data-mining environment, to analyze gene lists derived from high-throughput genomic experiments. The procedure first requires uploading a gene list containing any number of common gene identifiers followed by analysis using one or more text and pathway-mining tools such as gene functional classification, functional annotation chart or clustering and functional annotation table. By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies. SN - 1750-2799 UR - https://doi.org/10.1038/nprot.2008.211 DO - 10.1038/nprot.2008.211 ID - Huang2009 ER -