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TY - JOUR AU - Kim, So Young AU - Kim, Hyung-Jong AU - Lim, Hyun AU - Kong, Il Gyu AU - Kim, Miyoung AU - Choi, Hyo Geun PY - 2018 DA - 2018/08/06 TI - Bidirectional association between gastroesophageal reflux disease and depression: Two different nested case-control studies using a national sample cohort JO - Scientific Reports SP - 11748 VL - 8 IS - 1 AB - The purpose of this study is to evaluate the associations between gastroesophageal reflux disease (GERD) and depression using a national sample cohort of the Korean population. Data were collected from individuals ≥20 years old in the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2013. We designed two different nested case-control studies. In study I, 60,957 participants with depression were matched at a 1:4 ratio with 243,828 controls, and their previous histories of GERD were analyzed. In study II, 133,089 participants with GERD were matched at a 1:2 ratio with 266,178 controls, and their previous histories of depression were analyzed. Crude and adjusted odds ratios (ORs) were analyzed using unconditional logistic regression analyses, and 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed according to age and sex. The adjusted OR for GERD was 2.01 (95% CI = 1.96–2.07) in the patients with depression (study I). The adjusted OR for depression was 1.48 (95% CI = 1.43–1.52) in the patients with GERD (study II). The results of the subgroup analyses were consistent. GERD and depression displayed bidirectional associations. SN - 2045-2322 UR - https://doi.org/10.1038/s41598-018-29629-7 DO - 10.1038/s41598-018-29629-7 ID - Kim2018 ER -