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TY - JOUR AU - Martinowich, Keri AU - Lu, Bai PY - 2008 DA - 2008/01/01 TI - Interaction between BDNF and Serotonin: Role in Mood Disorders JO - Neuropsychopharmacology SP - 73 EP - 83 VL - 33 IS - 1 AB - Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are two seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. A common feature of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors (SSRIs) enhances BDNF gene expression. There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes. SN - 1740-634X UR - https://doi.org/10.1038/sj.npp.1301571 DO - 10.1038/sj.npp.1301571 ID - Martinowich2008 ER -