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TY - JOUR AU - Fraser, Hunter B. AU - Wall, Dennis P. AU - Hirsh, Aaron E. PY - 2003 DA - 2003/05/23 TI - A simple dependence between protein evolution rate and the number of protein-protein interactions JO - BMC Evolutionary Biology SP - 11 VL - 3 IS - 1 AB - It has been shown for an evolutionarily distant genomic comparison that the number of protein-protein interactions a protein has correlates negatively with their rates of evolution. However, the generality of this observation has recently been challenged. Here we examine the problem using protein-protein interaction data from the yeast Saccharomyces cerevisiae and genome sequences from two other yeast species. SN - 1471-2148 UR - https://doi.org/10.1186/1471-2148-3-11 DO - 10.1186/1471-2148-3-11 ID - Fraser2003 ER -