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TY - JOUR AU - Hertel, Jana AU - Lindemeyer, Manuela AU - Missal, Kristin AU - Fried, Claudia AU - Tanzer, Andrea AU - Flamm, Christoph AU - Hofacker, Ivo L. AU - Stadler, Peter F. AU - The Students of Bioinformatics Computer Labs 2004 and 2005 PY - 2006 DA - 2006/02/15 TI - The expansion of the metazoan microRNA repertoire JO - BMC Genomics SP - 25 VL - 7 IS - 1 AB - MicroRNAs have been identified as crucial regulators in both animals and plants. Here we report on a comprehensive comparative study of all known miRNA families in animals. We expand the MicroRNA Registry 6.0 by more than 1000 new homologs of miRNA precursors whose expression has been verified in at least one species. Using this uniform data basis we analyze their evolutionary history in terms of individual gene phylogenies and in terms of preservation of genomic nearness across species. This allows us to reliably identify microRNA clusters that are derived from a common transcript. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-7-25 DO - 10.1186/1471-2164-7-25 ID - Hertel2006 ER -